Image courtesy of James Monaghan, Ph.D., Northeastern University, Boston, MA

Engineering Limb Regeneration

Recapitulating Normal Development and Regeneration?

HELD: April 22, 2015

BioPharmaceutical Technology Center
5445 East Cheryl Parkway
Fitchburg/Madison, WI 53711


OVERVIEW: The Symposium was coordinated by the Stem Cell & Regenerative Medicine Center, at the University of Wisconsin-Madison and the BTC Institute. It brought together leading researchers who are working in the areas of limb development and regeneration (morning session) and stem cells and tissue engineering (afternoon session).


  • Historical perspectives on limb regeneration
  • The emergence of amphibians in relation to the ability to regenerate limbs
  • The role of epigenetic modifications that regulate limb regeneration in anurans and the relationships/differences of this to mammalian limb regeneration
  • The implications of recent studies on the newt transcriptome, including the possibility that urodeles use unique sets of genes in limb regeneration
  • Terminal phalanx regeneration in mammals regarding the Wnt signaling pathway and of nerves in allowing this regeneration
  • Future challenges to the generation of functional musculoskeletal tissues from stem cells and how developmental and regenerative biology can assist with this process
  • Regeneration of musculoskeletal tissues of a limb, including skeletal muscle, tendon/ligament, bone and cartilage, using stem cell-based engineering approaches


Jeremy Brockes, Ph.D., MRC Research Professor, Department of Structural and Molecular Biology, University College London, London, UK

David Butler, Ph.D., Emeritus Professor, Biomedical Engineering, University of Cincinnati, Cincinnati, OH

John Fallon, Ph.D., H.W. Mossman Professor Emeritus, Cell and Regenerative Biology Department, University of Wisconsin-Madison, Madison, WI (Moderator)

Johnny Huard, Ph.D., Professor, Departments of Orthopaedic Surgery, Microbiology and Molecular Genetics, Bioengineering, Pathology, Pediatrics, and Physical Medicine and Rehabilitation; Director of the Stem Cell Research Center, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA

Mayumi Ito, Ph.D., Associate Professor, The Ronald O. Perelman Department of Dermatology, Department of Cell Biology, New York University School of Medicine, New York, NY

Timothy J. Kamp, M.D., Professor, Medicine; Co-director, Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison (Welcome)

Lisa Larkin, Ph.D., Associate Professor, Molecular & Integrative Physiology, Biomedical Engineering Department, University of Michigan, Ann Arbor, MI

Wan-Ju Li, Ph.D., Assistant Professor, Department of Orthopedics and Rehabilitation, University of Wisconsin School of Medicine and Public Health, Madison, WI

William Murphy, Ph.D., Harvey D. Spangler Professor, Biomedical Engineering, College of Engineering, University of Wisconsin-Madison, Madison, WI

David Stocum, Ph.D., Professor and Dean Emeritus, Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN

Koji Tamura, Ph.D., Professor, Laboratory of Organ Morphogenesis, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan

Panagiotis Tsonis, Ph.D., Professor, College of Arts and Sciences: Biology, and School of Engineering: Bioengineering Graduate Program; Director, Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, OH

Ray Vanderby, Ph.D., Professor of Biomedical Engineering & Professor of Orthopedic Surgery, University of Wisconsin-Madison, Madison, WI (Moderator)



Congratulations to our Poster Contest winners: Thomas Lozito (1st place), David Belair (2nd place) and Ethan Lippmann (3rd place)!

2014 Symposium Summary

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