Wisconsin Human Proteomics Symposium

Post-Translational Modifications in Human Disease

August 7, 2015
BioPharmaceutical Technology Center, Madison, WI

8:30-9:30 Welcome:
Richard Moss, Ph.D. (Honorary Symposium Chair)

Keynote Address: Genotypic Variability and the Quantitative Proteotype
Ruedi Aebersold, Ph. D.
(Introduction: Lloyd M. Smith, Ph.D.)
9:30-10:00 Eric R. Strieter, Ph.D. (Moderator - Morning Session)

Phosphorylation-regulated Protein Dynamics in Kinase Regulation and Implications for Inhibitor Design: The Case of ERK2
Natalie Ahn, Ph.D.
10:00-10:15 BREAK
10:15-10:45 Dynamic Protein Modification in Metabolism and the Epigenome
John Denu, Ph.D.
10:45-11:15 An Edgotype of Chemoresistant Cells Reveals the Shaping of Epigenetic Regulatory Components
James Bruce, Ph.D.
11:15-11:45 Fast and Comprehensive Proteome Analysis
Joshua J, Coon, Ph.D.
1:15-1:45 Martha M. Vestling, Ph.D. (Moderator - Afternoon Session)

O-GlcNAcylation Serves as a Nutrient Sensor to Regulate Transcription, Signaling and Mitochondrial Function, and is a Major Molecular Basis of Glucose Toxicity in Diabetes
Gerald Hart, Ph.D.
1:45-2:15 Seeing Red and Going Green: Regulation of Eukaryotic Plasma Membrane Primary Transport Pumps by Phosphorylation, in Plants and Electric Fish
Michael R. Sussman, Ph.D.
2:15-2:45 Development and Application of MS-based Strategies for Qualitative and Quantitative Analysis of Protein and Peptide PTMs
Lingjun Li, Ph.D.
2:45-3:00 BREAK
3:00-3:30 A New Frontier in Proteomics: Identifying Proteoforms and Elucidating Proteoform Families from Measurements of Intact Mass and Lysine Count
Lloyd M. Smith, Ph.D.
3:30-4:00 Toward Top-Down Proteomics
Ljiljana Paša-Tolić, Ph.D.
4:00-4:30 Top-Down Proteomics for Comprehensive Analysis of Post-translational Modifications: Applications to Heart Disease
Ying Ge, Ph.D.
4:45-5:45 RECEPTION


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